Therapeutic Potential of Cancer Vaccine Based on MHC Class I Cryptic Peptides Derived from Non-Coding Regions

Therapeutic Potential of Cancer Vaccine Based on MHC Class I Cryptic Peptides Derived from Non-Coding Regions

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MHC class I molecules display intracellular peptides on cell surfaces to enable immune surveillance under pathological conditions.The source of MHC class I antigens responsible for cancer protection is probios intelliflora for dogs not fully understood.Here, we explored the MHC class I peptidome in mouse colon cancer cells using a proteogenomic approach.

We showed that cryptic peptides derived from unconventional short open reading frames accounted for part of the MHC class I peptidome.Moreover, cancer growth was significantly prevented in mice immunized with a cocktail of synthesized cryptic peptides.Together, our data showed that the source of cancer antigens was not limited to fragments of usssa pro m softballs consensus proteins.

Cryptic antigens were displayed by MHC molecules and mediated anti-cancer effects, suggesting their therapeutic potential for cancer prevention.